Summary. Anger is found among people who take Prozac, especially for people who are female, 50-59 old , have been taking the drug for 1 month, also take medication Xanax, and have Quit smoking. Prozac causes anger Ch3micalGirl. Hello I've been taking Prozac for three weeks now and today I had a huge breakdown. My sister annoyed me and I got really angry and I started to scream and cry and got very confused. It has long been known that many antidepressants cause akathisia, especially SSRIs (selective serotonin reuptake inhibitors), a category that includes Prozac, Paxil, Zoloft, and other commonly prescribed antidepressants. Can Depression Meds Cause Anger Issues? Joni Brown The diagnosis is depression and medication advised. It is now time for the patient to take an active role in the selection of an antidepressant. The physician takes a careful history of the symptoms and explains the various types of antidepressants and their side effects. One of the main concerns is the side effect of anger, so the patient. Prozac can cause this reaction as a rare side effect. It also can easily set off mania in someone with bipolar. You should talk this over with your psychiatrist as soon as possible including an evaluation of your diagnosis. All clinical material on this site is peer reviewed by one or more clinical psychologists or other qualified mental health professionals. Originally published by Dr Joseph M Carver, PhD on June 3, 2008 and last reviewed or updated by Dr Greg Mulhauser, Managing Editor on June 3, 2008. No real mention of extreme anger or irritability mentioned there. But if you read on… But if you read on… The 2006 U.K. study by Healy, Herxheimer, and Menkes observed that akathisia is often miscoded in antidepressant clinical trials as “agitation, emotional lability, and hyperkinesis (overactivity)”. My daughter has been taking 20mg of Prozac since August 2017 for severe anxiety. A few months into it she started having some depression (which there might have been some before anyway) that subsided and was replaced by tiredness and anger irritability. I was on prozac for almost 2 years and within the past 3 months I became extremely depressed and my anxiety worsened. I was switched to Cymbalta which has made a difference. I recently switched from Zoloft to Prozac because Zoloft was causing me serious hair loss issues. When I mentioned it to my pdoc he said, oh, yeah, Zoloft can cause hairloss, he's seen it plenty of times but only in women.